Publications by authors named "M A Heitkamp"
Background: Cluster headache (CH) is a significant health concern due to its major socioeconomic consequences and most patients being refractory to conventional strategies. For treatment resistant CH, occipital nerve stimulation (ONS) is considered an effective treatment option. Whereas most patients do not adjust the amplitude of the ONS system, a subset changes the amplitude on a regular basis using their remote control, and are therefore referred to as 'voltage tuners'.
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- Numerous guidelines emphasize the need for personalized interventions to combat childhood obesity, focusing on the influence of the FTO gene.
- A systematic review of 12,255 records evaluated 13 lifestyle-based obesity interventions involving nearly 4,000 children, analyzing changes in various obesity-related metrics.
- The findings indicated that the FTO risk allele had little impact on children's responses to these interventions, suggesting that genetic factors may have a minor role, and future research should explore the cumulative effects of multiple genes.
Article Synopsis
- Multiple lifestyle-based obesity interventions for children show varied effectiveness, with the impact of genetic variants on outcomes still unclear.
- *The study analyzed results from 50 research articles, finding that about 75% of investigated gene variants had no significant effect on obesity or metabolic indicators post-intervention.
- *Overall, the findings suggest that genetic factors have a minor influence on the success of obesity interventions, highlighting the need for more comprehensive studies.*
Background: Extensive physical activity (PA; ≥18 METh/week, MET metabolic equivalent of tasks hours) postcancer diagnosis has shown favorable effects on colorectal cancer disease-free survival. However, the feasibility of introducing this high volume of PA in this patient group is unclear. Therefore, the aim of the F-PROTECT study was to evaluate the feasibility of extensive and prolonged PA (≥18 METh/week over 12 months) in colorectal cancer patients with the primary objectives to (1) recruit 50 patients within 12 months and (2) reach an attendance rate of ≥70%.
View Article and Find Full Text PDFBackground: Exercise for heart failure (HF) with reduced ejection fraction (HFrEF) is recommended by guidelines, but exercise mode and intensities are not differentiated between HF etiologies. We, therefore, investigated the effect of moderate or high intensity exercise on left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and maximal exercise capacity (peak VO) in patients with ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM).
Methods: The Study of Myocardial Recovery after Exercise Training in Heart Failure (SMARTEX-HF) consecutively enrolled 231 patients with HFrEF (LVEF ≤ 35 %, NYHA II-III) in a 12-weeks supervised exercise program.