Urinary Iodine Concentration and Thyroid Hormone Metabolism in Pregnant Women and Neurodevelopment in Their Children: A Longitudinal Canadian Birth Cohort.

: Iodine is essential for thyroid hormone (TH) synthesis, and THs in pregnant women are critical for fetal brain development. It is unclear whether urinary iodine concentrations (UICs) are associated with thyroid parameters in pregnant women and neurodevelopment in their 3-4-year-old children. : In the Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) cohort, we categorized UIC adjusted for urinary creatinine (UIC/Cr) in the first two trimesters as <150, 150-500, or ≥500 µg/g.

How and why researchers and advocates should engage with state and local food policymaking.

Unhealthy diets contribute to one in every five deaths in the United States, yet federal policy action to improve dietary quality has been limited. We argue that researchers and advocates should engage in state and local food policymaking, which offers an important complementary avenue for creating healthier food environments and improving diet quality. We outline key questions researchers can address to inform local and state policymaking and provide practical tips on how they can engage with the policy process.

Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm.

Background: Cigarette smoking is a strong risk factor for cardiovascular harm.

Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.

Methods: We included 182,364 participants (mean age 58.

Unveiling distinct representations of P3a in schizophrenia through two-stimulus and three-stimulus auditory oddball paradigms.

Background: P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.

CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Importance: Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride into NAD+, resulting in an increase of cellular adenosine triphosphate production.

Objective: To determine the effects of CNM-Au8 on ALS disease progression.