Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles.

Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for the treatment of extrahepatic diseases, such as hematological disorders. Here we describe the specific targeting of LNPs to hematopoietic progenitor cells in the bone marrow.

A polynomial invariant for a new class of phylogenetic networks.

Invariants for complicated objects such as those arising in phylogenetics, whether they are invariants as matrices, polynomials, or other mathematical structures, are important tools for distinguishing and working with such objects. In this paper, we generalize a complete polynomial invariant on trees to a class of phylogenetic networks called separable networks, which will include orchard networks. Networks are becoming increasingly important for their ability to represent reticulation events, such as hybridization, in evolutionary history.

Alchemical Practice: Looking Towards the Chemical Humanities.

This special issue of Ambix is an outgrowth of the Tenth Annual Postgraduate Workshop titled "Society and the Creation of (al)Chemical Knowledge" hosted by the Embassy of the Free Mind in Amsterdam, 29-30 November 2019. This meeting of early career scholars with a shared interest in the history of alchemy and chemistry illustrated the diversity of methodological approaches that contribute to this subfield. Alchemical knowledge, created through practice, language, and material culture, has permeated society since the ancient world.