Publications by authors named "M A H Capelle"
Through a synergistic collaboration of people with varying backgrounds and expertise, the root-cause of respiratory syncytial virus prefusion (preF) protein aggregation during freezing was identified to be supercooling. This issue was addressed through a comprehensive understanding of the product. Leveraging innovative and unconventional methods, apparatus, and approaches, it was effectively determined that key parameters influencing aggregation were the nucleation temperature and the duration of supercooling.
View Article and Find Full Text PDFSeasonal influenza vaccines must be updated annually and suboptimally protect against strains mismatched to the selected vaccine strains. We previously developed a subunit vaccine antigen consisting of a stabilized trimeric influenza A group 1 hemagglutinin (H1) stem protein that elicits broadly neutralizing antibodies. Here, we further optimized the stability and manufacturability of the H1 stem antigen (H1 stem v2, also known as INFLUENZA G1 mHA) and characterized its formulation and potency with different adjuvants in vitro and in animal models.
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- The study aimed to see if a deep learning tool could tell the difference between two muscle diseases, FSHD1 and myositis, using whole-body MRI scans without needing doctors to check the images manually.
- They tested 40 patients: 19 with FSHD1 and 21 with myositis, and the deep learning tool performed well, getting about 69% to 77% of the diagnoses right depending on the body parts scanned.
- In comparison, two expert doctors also did well, but the deep learning tool was able to correctly identify more patients that the doctors got wrong, showing it’s a useful tool for medical diagnosis.
Achieving Universal Health Care in the Pacific: The need for nursing and midwifery leadership. Review Paper.
Lancet Reg Health West Pac
February 2022
The quality of healthcare services and outcomes in the Pacific vary widely, with some countries enjoying some of the world's longest life expectancies, others have high rates of maternal and child mortality and relatively low life expectancy. Nurses and midwives make up more than two thirds of the regional regulated healthcare workforce. This paper argues that if countries are to meet Universal Health Coverage nursing and midwifery leaders need to be explicitly involved in shaping policy at the highest levels of government to optimise individual and community health both now and in the future.
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