Regulatory network of competitively interacting RNAs and effectiveness of rectal tumors radiotherapy.

Background: Currently, rectal tumors radiotherapy effectiveness reaches an acceptable level only in a small number of patients (they have a complete clinical response), which is associated with the formation of malignant cells radioresistance. A comprehensive study that integrates various epigenetic parameters would explain a number of molecular mechanisms of rectal tumor cells radioresistance and identify new bio-markers. In the last decade, using high-through-put sequencing, the competitively interacting RNAs regulatory network (long non-coding RNAs, miRNAs and mRNAs) has been shown.

[Recurrent mixed parotid tumor localized in pharyngeal processus].

Tumors of pleomorhic adenoma parapharingeal space of the parotid gland amount for less than 20% of all salivary gland tumors. In most cases these tumors are benign, and pleomorphic (polymorphous) adenomas prevail among them (up to 80-90%). The frequency of their malignization varies from 3.

[Prognostic significance of some markers in cutaneous melanoma treated with different therapeutic modalities].

The paper discusses the prognostic significance of Ki-67, bcl-2 and HMB-45 markers in skin melanoma in the course of different modalities of chemotherapy involving autoblood. Recurrence-free and 3-year survival among patients receiving autoblood preparations was significantly higher than in controls (p < or = 0.05).

[Clinico-morpho-sonographic parallels in skin melanoma].

Data on sonographic features of different variants of skin melanoma are presented. Relationship between skin to tumor thickness ratio and invasion depth (Clark) or tumor thickness (Breslow) were found. Tumor extent was effectively identified by ultrasound tomography of primary focus preoperatively.