Publications by authors named "M A Graf"

Plastic mulch films support global food security, however, their composition and the potential release rates of organic, metal and metalloid co-contaminants remains relatively unknown. This study evaluates the low molecular weight organic additives, metal and metalloid content and leaching from low density polyethylene (LDPE) and biodegradable plastic mulch films. We identified 59 organic additives, and non-intentionally added substances in the new LDPE films (39.

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Background: The purpose of this retrospective study was to evaluate the value of contrast-enhanced computed tomography (CE-CT) image features at baseline and after neoadjuvant chemotherapy in predicting histopathological response in patients with adenocarcinoma of the gastroesophageal junction (GEJ).

Methods: A total of 105 patients with a diagnosis of adenocarcinoma of the GEJ were examined by CE-CT at baseline and preoperatively after neoadjuvant chemotherapy. All patients underwent surgical resection.

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Background: Impairments in behavioral pattern separation (BPS)-the ability to distinguish between similar contexts or experiences-contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested.

Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis.

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The research relevance is determined by the need for rational use of limited resources in the healthcare sector and the importance of implementing the results of scientific research into medical practice to improve the quality of medical care. The study aims to identify key criteria and develop a system for evaluating clinical trials to prioritise the most promising areas based on their practical applicability in healthcare. The expert evaluation method of 17 research projects in the field of clinical medicine funded by government grants, involving 37 experts, was used to achieve the objective.

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The claustrum is a small but densely interconnected brain structure that is innervated by axons containing serotonin (5-HT), a neuromodulator that has been implicated in control of sleep and in the actions of psychedelic drugs. However, little is known about how 5-HT influences the claustrum. We have combined whole-cell patch-clamp measurements of ionic currents, flash photolysis, and receptor pharmacology to characterize the 5-HT responses of individual claustral projection neurons (PNs) in mouse brain slices.

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