Rheumatoid Arthritis: A Rare Cause of Pachymeningitis and Optic Neuritis.

Introduction: Rheumatoid pachymeningitis and optic neuritis are rare complications of rheumatoid arthritis (RA) and are a diagnosis of exclusion.

Case Description: A 75-year-old male with a history of seronegative RA presented to the emergency department with left eye pain and blurry vision lasting two days. He had been diagnosed with seronegative RA around nine months previously.

Effective carbon footprint assessment strategy in fly ash geopolymer concrete based on adaptive boosting learning techniques.

In light of the growing need to mitigate climate change impacts, this study presents an innovative methodology combining ensemble machine learning with experimental data to accurately predict the carbon dioxide footprint (CO-FP) of fly ash geopolymer concrete. The approach employs adaptive boosting to enhance decision tree regression (DTR) and support vector regression (SVR), resulting in a robust predictive framework. The models used key material features, including fly ash concentration, fine and coarse aggregates, superplasticizer, curing temperature, and alkali activator levels.

The UBA1-STUB1 axis mediates cancer immune escape and resistance to checkpoint blockade.

How cancer cells escape immune surveillance and resist immune checkpoint blockade (ICB) remains to be fully elucidated. By screening candidate genes frequently gained in cancer, we identified expression of ubiquitin-like modifier activating enzyme 1 (UBA1) as being the most negatively correlated with signatures related to effector CD8+ T-cells. High UBA1 expression was strongly predictive of treatment resistance and poor survival in ICB cohorts.

Navigating a Complex Case of Hypoplastic Right Lung With Bronchiectasis: A Ten-Year Journey.

Unilateral pulmonary hypoplasia (UPH) is a rare congenital disorder that presents rarely in adulthood. Most patients succumb to complications at a young age, and those who survive are rare and susceptible to frequent lifelong pulmonary infections. It has a high infant mortality rate.

Cracking the Code: A Case Report on Low-Renin Hypertension.

Low-renin hypertension (LRH) is characterized by hypertension accompanied by low serum renin levels. LRH is a spectrum, including low-renin essential hypertension (LREH), primary hyperaldosteronism, and several acquired or familial secondary forms. Here, we present a case of LRH.