Background: Cold agglutinin disease (CAD) or syndrome (CAS) can be particularly challenging when autologous stem cell transplant (ASCT) is needed. Standard peripheral blood stem cell (PBSC) collection and manipulation involve ex vivo blood manipulations at lower than body temperature, predisposing to agglutination during graft collection, handling, processing, and infusion.
Study Design And Methods: We describe the first case of ASCT for relapsing lymphoma in a patient with high-titer CAD requiring anti-complement therapy and chronic transfusion.
Objective: The purpose of this guideline is to promote recognition and preventive strategies for obstetrical anal sphincter injuries. Furthermore, it provides guidance on primary repair and immediate postpartum management for obstetrical anal sphincter tears in order to minimize further negative sequelae.
Target Population: All patients having a vaginal delivery and those who have sustained an obstetrical anal sphincter injury.
This analysis aimed to (1) identify longitudinal joint trajectories of participation in organized and unorganized physical activity contexts, and level of daily moderate-to-vigorous physical activity (MVPA) and (2) assess whether basic psychological need satisfaction during adolescence differentiates between membership in different physical activity trajectories. Participants (n = 888; 56% girls) reported their involvement in 36 different physical activities, level of MVPA, and their perceived satisfaction of competence, autonomy, and relatedness satisfaction in physical activity up to three times per year, over 8 years (from ages 10 to 17 years). Group-based multi-trajectory models were used to identify longitudinal joint trajectories of physical activity participation.
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