Publications by authors named "M A Garrote"
Background: V617F-mutated myeloproliferative neoplasms (MPN) exhibit abnormal proliferation of bone marrow progenitors and increased risk of thrombosis, specifically in splanchnic veins (SVT). The contribution of the endothelium to the development of the prothrombotic phenotype was explored.
Material And Methods: Plasma and serum samples from V617F MPN patients with (n=26) or without (n=7) thrombotic debut and different treatments, were obtained (n=33).
Article Synopsis
- Hydroxyurea (HU) is the primary treatment for essential thrombocythemia (ET), but there are no clear guidelines for when to switch therapies.
- In a study of 1080 patients, 67% achieved a complete hematological response (CHR) after five years, with high-risk patients showing lower risks of arterial thrombosis if they achieved CHR.
- Patients with HU resistance or intolerance had a higher chance of developing myelofibrosis, but this did not significantly impact overall survival or thrombotic risk; CHR is linked to improved outcomes and may guide future treatment decisions.
: The aim of this study was to evaluate incidental findings in the mandible after the placement of dental implants using a new cone-beam computed tomography (CBCT) software. : The initial sample consisted of 2872 CBCT scans of patients of both sexes. The parameters evaluated in this study were the location of the implants in the mandible, implant length, anatomical relationship of the implant with the mandibular canal, presence or absence of damage to the adjacent teeth, presence or absence of implant fractures, and presence or absence of bone support.
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- Two new diagnostic classifications for acute myeloid leukemia (AML) were introduced in 2022 to enhance understanding of the disease's biology compared to the previous 2017 categories.
- A study involving whole exome sequencing on 69 patients with intermediate-risk AML revealed that 45% had their diagnostic category changed, with a notable increase in those classified as AML with myelodysplasia-related changes due to a high mutation frequency.
- The findings highlighted that specific gene mutations, particularly in the most commonly mutated gene, correlated well with myelodysplastic syndrome history, while also indicating that some newly diagnosed patients without prior dysplasia had these mutations, suggesting the need for a more unified classification system.