Publications by authors named "M A Garcia-Blanco"
Article Synopsis
- - The study focused on developing an mRNA vaccine for the Andes virus (ANDV) using two types of mRNA: regular uridine (U-mRNA) and N1-methylpseudouridine (m1Ψ-mRNA).
- - Mice showed better immune responses with the m1Ψ-mRNA, but both mRNA types led to similar activation and effective antibody responses in subsequent tests with Syrian hamsters.
- - The results indicate that the U-mRNA construct produced higher glycoprotein-binding antibodies, yet both vaccines effectively protected rodents from a lethal ANDV challenge, showing the vaccine's potential despite subtle differences.
DExD-box RNA proteins DDX39A and DDX39B are highly homologous paralogs that are conserved in vertebrates. They are required for energy-driven reactions involved in RNA processing. Although we have some understanding of how their functions overlap in RNA nuclear export, our knowledge of whether or not these proteins have specific or redundant functions in RNA splicing is limited.
View Article and Find Full Text PDFForkhead box P3 (FOXP3) is the master fate-determining transcription factor in regulatory T (T) cells and is essential for their development, function, and homeostasis. Mutations in cause immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, and aberrant expression of has been implicated in other diseases such as multiple sclerosis and cancer. We previously demonstrated that pre-mRNA splicing of RNAs is highly sensitive to levels of DExD-box polypeptide 39B (DDX39B), and here we investigate the mechanism of this sensitivity.
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- - The study aimed to assess how effective it is for students to learn to administer inferior alveolar nerve blocks (IANB) with or without practical simulator lessons compared to just theoretical instruction.
- - Students were randomly divided into two groups: one received both theory and practical lessons using a simulator, while the other only had theory. Results showed that those who used the simulator were better at handling instruments and had a hint of improved anatomical landmark recognition.
- - Although both groups had similar success rates in administering the IANB and felt equally confident, all students found training with the simulator to be beneficial.
The prevalence of cardiovascular diseases (CVDs) is a growing global health concern. Recent advances have demonstrated significant reductions in acute cardiovascular events through the management of modifiable cardiovascular risk factors. However, these factors are responsible for about 50% of the global cardiovascular disease burden.
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