Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis.

Ferroptosis is a novel form of cell death characterized by unlimited accumulation of iron-dependent lipid peroxides. It is often accompanied by disease, and the relationship between ferroptosis of immune cells and immune regulation has been attracting increasing attention. Initially, it was found in cancer research that the inhibition of regulatory T cell (Treg) ferroptosis and the promotion of CD8+ T cell ferroptosis jointly promoted the formation of an immune-tolerant environment in tumors.

Budget impact analysis of baricitinib for treatment of alopecia areata: A Saudi hospital perspective.

Objectives: To perform a budget impact analysis (BIA) of the adoption of baricitinib for the management of alopecia areata (AA) by a Saudi public sector payer.

Methods: A BIA model was developed to calculate the expected financial impact under two scenarios: the baseline scenario, which reflects the current mix of treatments without baricitinib, and the projected scenario, in which baricitinib is adopted. The model assumed that patients with severe AA and those with mild-to-moderate AA who did not respond to other treatments were eligible for baricitinib treatment.

Laparoscopic Hepaticojejunostomy. Initial experience in 21 consecutive cases.

Introduction: laparoscopic hepaticojejunostomy is a complex procedure indicated for different pathologies. Still, the laparoscopic approach is not the gold standard, but it is well known for its benefits regarding post operative recovery. We present our experience in 21 consecutive cases of laparoscopic hepaticojejunostomy done at King Fahad General Hospital in Jeddah.

Management of Fracture-Related Infection in Conflict Zones: Lessons Learned from Medical Missions to Gaza.

: Fracture-related infections (FRIs) are a significant complication in conflict zones, where limited resources and damaged infrastructure complicate orthopedic care. : This study retrospectively reviews the management of FRIs during medical missions to Gaza from April to July 2024. : Among 135 patients treated for war-related fractures, 30% were identified with suspected FRIs, which were primarily following explosive injuries.