DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.

Precursor messenger RNA (pre-mRNA) is processed into its functional form during RNA polymerase II (Pol II) transcription. Although functional coupling between transcription and pre-mRNA processing is established, the underlying mechanisms are not fully understood. We show that the key transcription termination factor, RNA exonuclease Xrn2 engages with Pol II forming a stable complex.

Single-Incision Peroneal Tendon Repair With Concomitant Modified Dwyer Calcaneal Osteotomy: Report of 15 Cases With Plate Fixation.

Background: Addressing hindfoot varus via calcaneal osteotomy with simultaneous peroneal tendon repair from a single incision has not been thoroughly assessed. Some concerns with one incision are wound complications, nerve damage, and symptomatic hardware.

Methods: Patients operated on by one surgeon May 2012 to January 2022 were retrospectively reviewed with minimum 2-year follow-up via in-person visit, telephone, and chart review.

Predictive value of a self-administered frailty screening questionnaire for the effectiveness of functional rehabilitation evaluated with the locomotor functional independence measure in a geriatric rehabilitation unit: a multicentre cohort study.

Background: Patient Reported Outcome Measures (PROMs) are questionnaires that collect health data directly from the patient, without any intervention from a third party. The aim of rehabilitation units is to restore function. Functional gain can be evaluated with classic scales, such as the locomotor subscale of the Functional Independence Measure.

In-situ monitoring of µm-sized electrochemically generated corrosion pits using Lamb waves managed by a sparse array of piezoelectric transducers.

Corrosion is a major threat in the aeronautic industry, both in terms of safety and cost. Efficient, versatile, and cost affordable solutions for corrosion monitoring are thus needed. Ultrasonic Lamb Waves (LW) appear to be very efficient for corrosion monitoring and can be made cost effective and versatile if emitted and received by a sparse array of piezoelectric elements (PZT).