Validation of Psychometric Tools for Assessing Fatigue, Mood, and Sleep Quality: Application in the PREVES-STOP Study.

: Environmental pollution in regions like the Sarno River Basin in southern Italy significantly affects physical and psychological health. This study aimed to validate three novel psychometric tools-REST, HEAL-BDLC, and PEACE-for assessing fatigue, mood disturbances, and sleep quality in environmentally exposed populations. While correlations with heavy metal exposure will be addressed in a separate manuscript, this study focuses solely on psychometric validation.

Large language models improve transferability of electronic health record-based predictions across countries and coding systems.

Variation in medical practices and reporting standards across healthcare systems limits the transferability of prediction models based on structured electronic health record (EHR) data. We introduce GRASP, a novel transformer-based architecture that enhances the generalizability of EHR-based prediction by embedding medical codes into a unified semantic space using a large language model. We applied GRASP to predict the onset of 21 diseases and all-cause mortality in over one million individuals from UK Biobank (UK), FinnGen (Finland) and Mount Sinai (USA), all harmonized to OMOP common data model.

Cumulative smoking exposure impacts oncologic outcomes of upper tract urothelial carcinoma.

Background: The impact of cumulative smoking exposure (CSE) on oncologic outcomes for upper tract urothelial carcinoma (UTUC) remains understudied. We examined the effect of this factor on oncologic outcomes in UTUC patients undergoing radical nephroureterectomy utilizing a large contemporary multicenter, multinational cohort.

Methods: Multicenter review of 1,730 patients across 17 institutions.

Functional validation of putative PIP-box promoters of Xanthomonas citri subsp. citri using GFP as a reporter.

Background: Plant-Inducible Promoter boxes (PIP-boxes) are conserved sequences found within the promoter regions of various genes in phytopathogenic bacteria, including the Gram-negative bacterium Xanthomonas citri subsp. citri (X. citri), the causative agent of citrus canker.

Predictors and outcome of deterioration during admission in patients with cerebral venous thrombosis.

Introduction: Cerebral venous thrombosis (CVT) is a less common stroke subtype. While long term outcome factors have been extensively studied, short term deterioration remains poorly understood.

Patients And Methods: We conducted a 10-years retrospective analysis at a high-volume tertiary center, including consecutive patients diagnosed with CVT.