Publications by authors named "M A Febbraio"
Once thought to be in a terminally differentiated state, macrophages are now understood to be highly pliable, attuned and receptive to environmental cues that control and align responses. In development of purpose, the centrality of metabolic pathways has emerged. Thus, macrophage inflammatory or reparative phenotypes are tightly linked to catabolic and anabolic metabolism, with further fine tuning of specific gene expression patterns in specific settings.
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- The study investigated whether BGP-15 can enhance sperm quality and protect against cell damage in both mouse and human sperm.
- Mice sperm were treated with BGP-15 and assessed for quality, with findings showing improved motility and reduced DNA oxidation in older specimens.
- Human sperm exposed to oxidative stress also benefited from BGP-15, with the treatment improving sperm parameters, reinforcing its potential role in fertility treatments.
Cardiovascular disease (CVD) is a leading cause of mortality, affecting ∼18 million individuals each year. Obesity and type 2 diabetes mellitus in particular, both chronic metabolic disorders, are risk factors for CVD. The salutary effects of physical activity in preventing and ameliorating CVD have long been acknowledged, as it improves glucose and lipid homeostasis, alongside attenuating oxidative damage, increasing mitochondrial function, and ultimately improving cardiac function.
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- The causes of autism spectrum disorder (ASD) are not fully understood, but over 1,000 rare genetic variations are linked to the condition, complicating the search for common biological targets for therapy.
- CAMK4, a gene encoding an enzyme critical for brain development and function, has emerged as a potential risk gene for ASD, particularly in connection to certain genetic variants related to hyperkinetic movement disorders.
- The review emphasizes that defects in the CaMK4 signaling pathway may play a significant role in ASD pathogenesis, suggesting it as a promising target for future therapeutic interventions.
Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. The purpose of this study was to examine the mechanisms behind the protective effects of exercise.
Methods: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden.