Factors contributing to persistent shoulder pain after arthroscopic rotator cuff repair: Protocol for a scoping review.

Introduction: Rotator cuff (RC) tears are the most common and disabling musculoskeletal ailments among patients with shoulder pain. Although most individuals show improvement in function and pain following arthroscopic rotator cuff repair (ARCR), a subgroup of patients continue to suffer from persistent shoulder pain following the surgical procedure. Identifying these factors is important in planning preoperative management to improve patient outcomes.

Ultrasensitive Detection and Monitoring of Circulating Tumor DNA using Structural Variants in Early-Stage Breast Cancer.

Purpose: The detection of circulating tumor DNA (ctDNA) after curative-intent therapy in early breast cancer (EBC) is highly prognostic of disease recurrence. Current ctDNA assays, mainly targeting single nucleotide variants (SNVs), vary in sensitivity and specificity. While increasing the number of SNVs in tumor-informed assays improves sensitivity, structural variants (SVs) may achieve similar or better sensitivity without compromising specificity.

Public Health.

Background: Neighborhood conditions and their racial patterning represent under-studied factors that could contribute to racial disparities in dementia risk. Neighborhood socioeconomic status (SES) has been linked to dementia, but the racial distribution of SES within a neighborhood may also matter for dementia risk.

Method: Individual-level data from 460 (47% Black, 46% White, 7% other) older adults from the Michigan Cognitive Aging Project (Table 1) were linked to census tract-level data from the National Neighborhood Data Archive.

Biomarkers.

Background: Aging is the strongest risk factor for Alzheimer's disease (AD). Accordingly, identifying biomarkers of accelerated aging is a major focus of AD prevention research. Current MRI-based "aging clocks" (i.

Developing Topics.

Background: Regional brain atrophy estimated from structural MRI is the most widely used measure of neurodegeneration in Alzheimer's disease (AD), Frontotemporal Lobar Degeneration (FTLD), and other dementias. Yet, traditional MRI-derived morphometric estimates are susceptible to measurement errors, posing a challenge for reliably detecting longitudinal atrophy, particularly over short intervals. We examined the utility of multiple accelerated MRI scans acquired in rapid succession (i.