Publications by authors named "M A El Sharouni"
Background: Only a small per cent of new melanocytic lesions developing in adults are expected to represent melanomas. Total body photography (TBP) has been widely incorporated in clinical practice, especially for follow-up of high-risk individuals with multiple naevi. However, dynamic changes detected with TBP need to be interpreted with caution to avoid unnecessary excisions.
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- The study focuses on measuring the size of melanoma tumors in sentinel nodes (SN) to decide on additional treatment for patients with stage III melanoma.
- Measuring these tumors accurately is very important, especially when the size is around 1.0 mm.
- The research showed that different pathologists often get different measurements for the same tumors, which can affect treatment decisions, especially if there are many small tumors involved.
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- Recent trials showed benefits of using adjuvant systemic therapy (pembrolizumab/nivolumab) for stage IIB or IIC melanoma, but also highlighted risks. Accurate predictions for recurrence-free survival (RFS) and overall survival (OS) can help patients balance risks and benefits.
- Researchers created a multivariable risk prediction calculator using data from 3,220 stage II melanoma patients to estimate 5- and 10-year RFS and OS more accurately than the current AJCC-8 staging model.
- The new MIA models demonstrated better prediction accuracy (C-statistics) for RFS and OS compared to AJCC-8 models and were validated externally
Predicting who will benefit from treatment with immune checkpoint inhibition (ICI) in patients with advanced melanoma is challenging. We developed a multivariable prediction model for response to ICI, using routinely available clinical data including primary melanoma characteristics. We used a population-based cohort of 3525 patients with advanced cutaneous melanoma treated with anti-PD-1-based therapy.
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