Publications by authors named "M A Eichmann"
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Diabetologia
October 2022
Article Synopsis
- Enteroviral infections may play a significant role in the development of type 1 diabetes and autoimmune responses, potentially linked to genetic factors like the IFIH1 gene.
- Increased detection of enterovirus RNA was found in the cellular compartment of blood, particularly in children with autoimmune characteristics, suggesting a stronger association with enteroviral presence.
- Carriers of a specific allele of the IFIH1 gene were more likely to test positive for enterovirus RNA, but no link was found between this genetic variant and the presence of enteroviral proteins in the pancreatic islets of type 1 diabetes donors.
Background/aims: The aim of this work is to compare Monte Carlo simulated absorbed dose distributions obtained from Ru eye plaques, whose heterogeneous emitter distribution is known, with the common homogeneous approximation. The effect of these heterogeneities on segmented structures at risk is analyzed using an anthropomorphic phantom.
Methods: The generic CCA and CCB, with a homogeneous emitter map, and the specific CCA1364 and CCB1256 Ru eye plaques are modeled with the Monte Carlo code PENELOPE.
Follicular helper T (T) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether T cells were decreased by costimulation blockade using the CTLA-4-immunoglobulin (Ig) fusion protein (abatacept) in a mouse model of diabetes and in individuals with new-onset T1D. Unbiased bioinformatics analysis identified that inducible costimulatory molecule (ICOS) T cells and other ICOS populations, including peripheral helper T cells, were highly sensitive to costimulation blockade.
View Article and Find Full Text PDFPurpose Of Review: The role of T cells specific for islet autoantigens is proven in pathogenesis of type 1 diabetes. Recently, there has been rapid expansion in the number of T-cell subsets identified, this has coincided with an increase in the repertoire of reported islet antigens mainly through the discovery of novel epitopes. A discussion of how these marry together is now warranted and timely.
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