Publications by authors named "M A Dubbelman"
Objectives: We aimed to compare and link the total scores of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), two common global cognitive screeners.
Methods: 2,325 memory clinic patients (63.2 ± 8.
Unlabelled: With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify subgroups most likely to benefit from specific treatments and thus inform future trial design. In this perspective, we report on our effort to pool data from past Alzheimer's disease trials to identify patients most likely to respond to different treatments.
View Article and Find Full Text PDFBackground: Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer's disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) pathology of speech acoustics measured over multiple assessments in a remote setting.
Methods: Fifty cognitively unimpaired adults (Age 68 ± 6.
Article Synopsis
- The study examines how changes in everyday functioning, particularly through a phone task, relate to tau and amyloid levels in cognitively healthy older adults.
- Seventy-six participants were assessed over approximately two years, using tasks that simulated real-life activities like refilling prescriptions and selecting doctors.
- The results found that higher levels of baseline amyloid and tau were linked to a faster decline in performance on one specific task (APT-PCP), suggesting early indicators of cognitive decline can be detected through these assessments.
Objective: The Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) is well validated and commonly used to assess difficulties in everyday functioning regarding dementia. To facilitate interpretation and clinical implementation across different European countries, we aim to provide normative data and a diagnostic cutoff for dementia.
Methods: Cross-sectional data from Dutch Brain Research Registry ( = 1,064; mean () age = 62 ± 11 year; 69.