Anti-infective monoclonal antibodies: perils and promise of development.

So far, most monoclonal antibodies have been developed for treating cancer or immunological diseases. However, the global spread of infections such as West Nile and corona viruses, and the need to address the potential threat of bioterrorism, has boosted public interest in, and government support of, counter-measures for infectious diseases. The attractive features of monoclonal antibodies, such as high specificity and effective recruitment of the immune system, would seem to make them excellent candidates as anti-infective agents.

Monoclonal antibody successes in the clinic.

Most monoclonal antibodies in clinical trials are owned by small biotech companies. But with blockbuster-sized revenues and approval rates higher than those for small-molecule drugs, that all may be set to change.

Charnley low-friction arthroplasty of the hip. Twenty-year results with cement.

The first 333 Charnley (Thackray, United Kingdom) total hip arthroplasties performed at the Mayo Clinic between 1969 and 1970 have been followed since that time. One hundred twelve patients (112 hips) remain alive at 20 years. Clinical results remain excellent.

Charnley total hip arthroplasty with cement. Fifteen-year results.

The results of the first 333 Charnley total hip arthroplasties that were performed with cement at the Mayo Clinic were reviewed a minimum of fifteen years postoperatively. Data were available for 166 of 170 hips of patients who were still alive. One hundred and thirty patients died, and thirty-seven hips were revised.

Radiographic measurements of the normal adult foot.

Various radiographic measurements of the normal adult foot have been reported in both early and recent literature; however, a complete description of radiographic quantitative data has yet to be reported. The purpose of this study is to describe the range of the normal foot using standard radiographic techniques that can be applied to the clinical setting. This should provide the data necessary for the accurate interpretation of foot radiographs.