Publications by authors named "M A De Matteis"
Article Synopsis
- The study investigates the role of a protein called CCDC158 in kidney function, specifically in the reabsorption of proteins in the renal proximal tubules, highlighting its importance in kidney and reproductive health.
- Whole exome sequencing identified a missense variant in CCDC158 in a male patient with kidney issues, which also appeared in a sister with similar symptoms, suggesting a hereditary component.
- Functional analyses showed that CCDC158 likely interacts with other proteins involved in endocytosis, affecting kidney function and contributing to conditions like proteinuria and oligospermia, but further research is needed to clarify its exact mechanisms.
Background: This work aimed to study the Village Test (VT) in a group of patients with Alzheimer's disease (AD) and compare the results with those of a group of patients with mild cognitive impairment (MCI) and controls.
Methods: A total of 50 patients with AD, 28 patients with MCI, and 38 controls were evaluated. All participants underwent the VT and an extensive neuropsychological evaluation.
Article Synopsis
- The study investigates the effectiveness of the Italian Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in differentiating between Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), and healthy controls (HC).
- The research involved 137 patients randomly assigned to MCI, AD, and HC groups and employed statistical analyses to identify tests that effectively distinguished between these groups.
- Results indicated that specific episodic memory tests from the I-UDSNB, particularly the Craft Story and Five Words tests, showed significant differentiation between MCI, AD, and HC, confirming the battery's reliability for assessing cognitive decline.
The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe what is known about the host factors and viral proteins involved in the replication, assembly, and egress phases of SARS-CoV-2, which induce significant host membrane rearrangements.
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