No impact of graft size or time to surgery on anterior tibial translation under weight-bearing following ACL reconstruction.

Purpose: The aim of this study is to evaluate the impact of graft size and time between injury to surgery (TBIS) on static anterior tibial translation (SATT) and dynamic anterior tibial translation (DATT) after anterior cruciate ligament (ACL) reconstruction.

Methods: A consecutive series of patients treated with primary ACL reconstruction using hamstring autograft was reviewed. Preoperative SATT, DATT and posterior tibial slope (PTS) were measured with a previously validated technique by two independent reviewers on lateral weight-bearing knee radiographs.

Canopy functional trait variation across Earth's tropical forests.

Tropical forest canopies are the biosphere's most concentrated atmospheric interface for carbon, water and energy. However, in most Earth System Models, the diverse and heterogeneous tropical forest biome is represented as a largely uniform ecosystem with either a singular or a small number of fixed canopy ecophysiological properties. This situation arises, in part, from a lack of understanding about how and why the functional properties of tropical forest canopies vary geographically.

A highly sensitive one-step nanobody-based immunoassay to specifically detect antibodies against fowl adenovirus serotype 4.

Hepatitis-hydropericardium syndrome, caused by fowl adenovirus serotype 4 (FAdV-4), has resulted in significant economic damage to the poultry industry. To monitor viral exposure and vaccine efficacy, some traditional antibody-based immunoassays have been developed for detecting anti-FAdV-4 antibodies. However, these assays have some drawbacks including multi-step operations and higher production cost.

Structural analysis of substrate recognition loop flexibility in D-arabinose dehydrogenase from Candida auris.

Candida auris is an emerging fungal pathogen that poses a significant threat to global health due to its multidrug resistance and ability to persist in healthcare settings. A key factor contributing to its survival and virulence is its capacity to combat oxidative stress, a process primarily driven by oxidative stress-related enzymes. One such enzyme, d-arabinose dehydrogenase from C.

Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial.

HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor receptor 1-3. The safety, pharmacokinetics, and efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) and advanced RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, ClinicalTrials.