Another face of RASA1: Report of familial germline variant in RASA1 with dysmorphic features.

RASopathies encompass a diverse set of disorders affecting genes that encode proteins within the RAS-MAPK pathway. RASA1 mutations are the cause of an autosomal dominant disorder called capillary malformation-arteriovenous malformation type 1 (CM-AVM1). Unlike other RASopathies, facial dysmorphism has not been described in these patients.

Sinc method for generating and extending phase screens of atmospheric turbulence.

We present a method, based on sinc series approximation, for generating and extending phase screens of atmospheric turbulence in real time to arbitrary lengths. Unlike phase screen representations based on the Fourier series, the sinc approximation is naturally suited to problems on infinite domains and thus avoids the problem of artificial periodicity inherent in the Fourier series. In particular, phase screens generated using the sinc method have accurate non-periodic statistics throughout the computational domain.

Numerical simulation of optical propagation using sinc approximation.

This paper further develops a recently proposed method for computing the diffraction integrals of optics based on sinc series approximation by presenting a numerical implementation, parameter selection criteria based on rigorous error analysis, and example optical propagation simulations demonstrating those criteria. Unlike fast Fourier transform (FFT)-based methods that are based on Fourier series, such as the well-known angular spectrum method (ASM), the sinc method uses a basis that is naturally suited to problems on an infinite domain. As such, it has been shown that the sinc method avoids the problems of artificial periodicity inherent in the ASM.

[Analysis of a clinical ethics committee activities at a general hospital].

Background: Clinical Ethics Committees are deliberative groups whose main functions are to assess cases with ethical-clinical conflicts, to generate institutional protocols for preventive purposes, and to train health teams.

Aim: To analyze the activity of a clinical ethics committee of a general hospital in the period 2007-2020.

Material And Methods: A retrospective analysis of all session records, annual reports, case resolution and documents generated by the Clinical Ethics Committee of Carlos van Buren Hospital in Valparaíso, Chile, between 2007 and 2020, was carried out.