Publications by authors named "M A Comini"
Article Synopsis
- The study explored genetic links to neuropathic pain by comparing individuals with the condition to those who had injuries but did not experience neuropathic pain.
- Key findings included significant associations with the KCNT2 gene and pain intensity, as well as other genes like LHX8 and TCF7L2 connected to neuropathic pain.
- The research also highlighted the influence of polygenic risk scores related to depression and inflammation on neuropathic pain, while discovering novel genetic variants tied to specific sensory profiles.
Article Synopsis
- Significant advancements have been made in understanding how nociceptors, pain-sensing neurons, convert damaging stimuli into pain signals, primarily through specific ion channels.
- Mutations in certain ion channels, like the voltage-gated sodium channel Na1.7, have been tied to inherited pain disorders, with loss-of-function mutations leading to an inability to feel pain and gain-of-function mutations causing various painful conditions.
- Other ion channels, such as TRPA1, and variants in VGSCs 1.8 and 1.9, have also been associated with pain disorders, highlighting the potential for targeting these channels in developing new pain medications and tailoring existing treatments based on genetic profiles.
Human African trypanosomiasis (HAT, sleeping sickness) and American trypanosomiasis (Chagas disease) are endemic zoonotic diseases caused by genomically related trypanosomatid protozoan parasites ( and , respectively). Just a few old drugs are available for their treatment, with most of them sharing poor safety, efficacy, and pharmacokinetic profiles. Only fexinidazole has been recently incorporated into the arsenal for the treatment of HAT.
View Article and Find Full Text PDFAssisted reproductive techniques are routinely used in livestock species to increase and enhance productivity. Ovarian hyperstimulation is a process that currently relies on administering pituitary-derived follicle-stimulating hormone (FSH) or equine chorionic gonadotropin in combination with other hormones to promote the maturation of multiple follicles and thereby achieve superovulation. The use of partially purified preparations of FSH extracted from natural sources is associated with suboptimal and variable results.
View Article and Find Full Text PDFSelenosugars targeting the infective stage of Trypanosoma brucei with high selectivity.
Int J Parasitol Drugs Drug Resist
April 2024
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC 0.5 and 1.5 μM) but poorly selective (selectivity index <10).
View Article and Find Full Text PDF