Publications by authors named "M A Colvin"
Introduction/aims: While dystrophinopathies are primarily characterized by progressive muscle weakness with onset during childhood, dystrophin also plays a role in brain development. This study aimed to characterize how neurodevelopmental and psychiatric disorders are currently identified and managed in clinical care of those with Becker and Duchenne muscular dystrophy (BDMD).
Methods: Parent Project Muscular Dystrophy (PPMD) disseminated surveys to caregivers and health care providers (HCPs) in the United States to assess the frequency and management of neurodevelopmental and psychiatric disorders of those with dystrophinopathy.
Article Synopsis
- Pediatric patients with dystrophinopathies often experience a range of neurodevelopmental and neuropsychiatric issues, prompting a study to evaluate a new screening tool (BELS) for identifying these challenges.
- 45 caregivers of BDMD patients completed the BELS questionnaire, alongside other established assessments, revealing high rates of behavioral, emotional, learning, and social concerns, as well as significant instances of passive suicidality.
- The BELS questionnaire showed strong correlations with other validated tools and could help in recognizing symptoms that need further attention, ultimately aiming to enhance clinical care and improve patients' quality of life.
Owing to their synthetic accessibility and protein-mimetic features, peptides represent an attractive biomolecular building block for the fabrication of artificial biomimetic materials with emergent properties and functions. Here, we expand the peptide building block design space through unveiling the design, synthesis, and characterization of novel, multivalent peptide macrocycles (96mers), termed coiled coil peptide tiles (CCPTs). CCPTs comprise multiple orthogonal coiled coil peptide domains that are separated by flexible linkers.
View Article and Find Full Text PDFMajor depressive disorder (MDD) is highly prevalent in youth and generally characterized by psychiatric comorbidities. Secular trends in co-occurring diagnoses remain unclear, especially in healthcare settings. Using large-scale electronic health records data from a major U.
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- Cardiac surgery and cardiology have the lowest representation of women and racial minorities compared to other medical specialties.
- * The underrepresentation of these groups is even more critical given that heart failure risk is increasing in the US, especially among non-white patients.
- * Increasing diversity in academia is vital for improving workforce representation, which will ultimately enhance patient care.