Publications by authors named "M A Colucci"
Kinship determination is a valuable tool in forensic genetics, with applications including familial searching, disaster victim identification, and investigative genetic genealogy. Conventional typing of small numbers of autosomal short tandem repeats (STRs) confidently identifies only first-degree relatives. Massively parallel sequencing (MPS) can access more STRs and resolve alleles identical by length but differing in sequence (isoalleles), which may increase the power of kinship estimation, particularly when combined with additional sequenced single nucleotide polymorphism (SNP) loci, as in the ForenSeq DNA Signature Prep kit.
View Article and Find Full Text PDFBackground: The Mobility Scale for Acute Stroke Patients (MSAS) was developed to discriminate between the lower levels of mobility in acute stroke patients in the first two weeks post-onset.
Objective: The present study aims to develop and validate an Italian version of the MSAS.
Methods: The English version of the MSAS was translated into Italian according to international guidelines.
Background: Bioaerosols can represent a danger to health. During SARS-CoV-2 pandemic, portable devices were used in different environments and considered a valuable prevention tool. This study has evaluated the effectiveness of the air treatment device "AEROK 1.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how coagulation factor X (FX) impacts tumor growth in castration-resistant prostate cancer (CRPC) by examining the prostate tumor microenvironment in mouse models through single-cell RNA sequencing.
- It finds that immunosuppressive neutrophils (PMN-MDSCs) produce FX, which activates pathways that enhance tumor cell growth independent of androgens, indicating a role for FX in cancer progression.
- Targeting FXa could impede the oncogenic function of PMN-MDSCs and potentially improve treatment outcomes when combined with existing therapies, with high levels of FX and related markers correlating to worse survival in CRPC patients.
Article Synopsis
- Immune-checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with immune-mediated pneumonitis (im-PN) being a rare but serious complication that requires prompt diagnosis and management to prevent severe outcomes and allow for continued cancer treatment.
- A study collected data from 1004 cancer patients treated with ICIs, finding that 24 (2%) developed im-PN, with varying degrees of severity; most patients responded well to steroid treatment, leading to recovery in 21 individuals within an average of 14 weeks.
- Three main radiologic patterns of im-PN were identified (organizational pneumonia-like, pulmonary eosinophilia, and hypersensitivity pneumonitis), and bronchoalve