Publications by authors named "M A Clavel"
Patients suffering from von Willebrand disease (VWD) have reduced quality-of-life despite current treatment options. Moreover, innovation in VWD therapeutic strategies has essentially stalled and available treatments have remained unchanged for decades. Therefore, there is an unmet need to develop new therapeutic strategies for VWD-patients, especially for the large portion of those with VWD-type 1.
View Article and Find Full Text PDFOver the past 15 years, sex-related differences in aortic valve (AV) stenosis (AS) have been highlighted, affecting various aspects of AS, such as the pathophysiology, AV lesions, left ventricle remodelling, and outcomes. Female patients were found to present a more profibrotic pattern of leaflet remodelling and/or thickening, whereas male patients have a preponderance of calcification within stenosed leaflets. The understanding of these sex differences is still limited, owing to the underrepresentation of female patients in many basic and clinical research studies and trials.
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- * This study used cardiac magnetic resonance (CMR) imaging to evaluate myocardial health and found that increased interstitial fibrosis (measured by extracellular volume fraction, ECV%) correlates with worse health outcomes in these patients.
- * Over a median follow-up of 5.7 years, higher ECV% was linked to increased mortality and heart failure admissions, indicating that ECV% could be a valuable tool for identifying patients needing closer monitoring.