Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.

Increasing evidence supports the role of the placenta in neurodevelopment and in the onset of neuropsychiatric disorders. Recently, mQTL and iQTL maps have proven useful in understanding relationships between SNPs and GWAS that are not captured by eQTL. In this context, we propose that part of the genetic predisposition to complex neuropsychiatric disorders acts through placental DNA methylation.

The earliest human face of Western Europe.

Who the first inhabitants of Western Europe were, what their physical characteristics were, and when and where they lived are some of the pending questions in the study of the settlement of Eurasia during the Early Pleistocene epoch. The available palaeoanthropological information from Western Europe is limited and confined to the Iberian Peninsula. Here we present most of the midface of a hominin found at the TE7 level of the Sima del Elefante site (Sierra de Atapuerca, Spain), dated to between 1.

Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024.

We estimated the effectiveness of the adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during the BA.

THE POSTERIOR MEDIAN SULCUS APPROACH TO A CAVERNOMA OF THE MEDULLAR OBLONGATA: A STEP-BY STEP VIDEO GUIDE.

Objective: Cavernous malformations of the brainstem (BSCM) often cause severe morbidity and mortality. Literature is limited for the optimal surgical approach. Our objective is to demonstrate successful use of the posterior median sulcus to access BSCM.

Unveiling the role of poly(vinyl alcohol) in the production of mucus-penetrating PLGA nanoparticles.

Mucosal drug delivery offers a promising non-invasive approach in pharmaceutical sciences but faces challenges from the protective mucus layer on mucosal surfaces, limiting drug absorption. Polymeric nanoparticles (NPs) have emerged as effective carriers, leveraging their small size to enhance mucus penetration and drug absorption. This study investigates polyvinyl alcohol (PVA)'s role in enhancing poly(lactic-co-glycolic acid) (PLGA) NPs for mucosal drug delivery.