Publications by authors named "M A Charbit"
Background: Epstein-Barr virus (EBV) is a herpesvirus linked to nine different human tumors and lymphoproliferative disorders. Immunosuppression promotes EBV-driven malignancies. The most frequent EBV-induced malignancies are lymphomas and nasopharyngeal carcinoma.
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- Autoimmune polyendocrine syndrome type-1 (APS-1) is linked to mutations in the AIRE gene, leading to multiple autoimmune issues and neutralizing antibodies that cause conditions like mucosal candidiasis and susceptibility to viral infections.
- Ruxolitinib, a JAK inhibitor, was successfully used off-label to treat three APS-1 patients over 30 months without any adverse effects, showing significant improvement in various autoimmune symptoms.
- These findings indicate that JAK inhibitors could be a promising treatment for APS-1 and that further research is warranted to evaluate their effectiveness across a larger patient population.
In this retrospective cohort study, we analyze the early humoral and cellular response in 64 adolescents KTx recipients, after two or three doses of mRNA vaccine BNT162b2 against different variants of COVID-19. After 2 doses, 77.8% % of children with no history of infection had a positive humoral response with a median anti-S IgG level of 1107 (IQR, 593-2,658) BAU/mL.
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