Clinical and cognitive outcomes in first-episode psychosis: focus on the interplay between cannabis use and genetic variability in endocannabinoid receptors.

Introduction: Research data show the impact of the endocannabinoid system on psychosis through its neurotransmission homeostatic functions. However, the effect of the endocannabinoid system genetic variability on the relationship between cannabis use and psychosis has been unexplored, even less in first-episode patients. Here, through a case-only design, we investigated the effect of cannabis use and the genetic variability of endocannabinoid receptors on clinical and cognitive outcomes in first-episode psychosis (FEP) patients.

"I Don't Understand How These Two Things Go Together": Toward a Theory of Risk Ecologies.

Rhetorical ecological approaches, which posit that messages exist not as isolated entities but instead in the relations of a dynamic network, offer a valuable lens for examining the discursive construction of health-related risk. Drawing from interview data ( = 50) exploring maternal vaccine refusal, this article expands upon these frameworks to trace how intertextual, synchronous messages - particularly those associated with prenatal and infant nutrition - influence mothers' understanding about early childhood vaccine-related risk. Ultimately, I propose the notion of a risk ecology - a network of intertextual messages which shape and constrain sense-making about risk as it emerges within a particular moment and biosocial community.

New substituted benzoxazine derivatives as potent inducers of membrane permeability and cell death.

The search for new agents targeting different forms of cell death is an important research focus for developing new and potent antitumor therapies. As a contribution to this endeavor, we have designed and synthesized a series of new substituted 3,4-dihydro-2H-1,4-benzoxazine derivatives. These compounds have been evaluated for their efficacy against MCF-7 breast cancer and HCT-116 colon cancer cell lines.

Improving Clinician Awareness of and Screening for Chagas Disease with an Educational Intervention.

Chagas disease is an underrecognized, chronic, and potentially life-threatening disease caused by the parasite Trypanosoma cruzi. We aimed to improve awareness and screening for Chagas disease among patients from endemic areas using a large safety-net academic hospital system in the United States. We developed an educational intervention consisting of a case-based didactic session presented to physicians, trainees, and other healthcare providers at conferences across different departments.