The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.

Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondria-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated with mitochondrial dysfunction across both clinical and pre-clinical models. Herein, we investigated the impact of 8-week ELAM treatment on pre- and post-measures of C57BL/6J mice frailty, skeletal muscle, and cardiac muscle function, coupled with post-treatment assessments of biological age and affected molecular pathways.

Don't ignore the tough questions: A qualitative investigation into occupational stressors impacting veterinarians' mental health.

Objective: To explore Canadian clinical veterinarians' perspectives of occupational stressors. Although extant research has emphasized quantitative reporting of workplace stressors in veterinary medicine, a qualitative approach can lend depth and context.

Procedure: One-on-one interviews were conducted with 25 veterinarians at the 2016 Canadian Veterinary Medical Association Conference.

Quantifying the ecological role of crocodiles: a 50-year review of metabolic requirements and nutrient contributions in northern Australia.

The ecological roles of large predators are well recognized, but quantifying their functional impacts remains an active area of research. In this study, we examined the metabolic requirements and nutrient outputs of the estuarine crocodile population () in northern Australia over a 50-year period, during which the population increased from a few thousand to over 100 000 individuals. Bioenergetic modelling showed that during this period, the crocodile population's annual prey consumption increased from <20 kg km in 1979 to approximately 180 kg km in 2019.

Dopamine in the tail of the striatum facilitates avoidance in threat-reward conflicts.

Responding appropriately to potential threats before they materialize is critical to avoiding disastrous outcomes. Here we examine how threat-coping behavior is regulated by the tail of the striatum (TS) and its dopamine input. Mice were presented with a potential threat (a moving object) while pursuing rewards.

Search for Highly Ionizing Particles in pp Collisions during LHC Run 2 Using the Full MoEDAL Detector.

This search for magnetic monopoles (MMs) and high electric charge objects (HECOs) with spins 0, 1/2, and 1, uses for the first time the full MoEDAL detector, exposed to 6.46  fb^{-1} proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production.