Publications by authors named "M A Camilletti"
Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary hormone-producing cell types as organoids. Wounding and physiological challenges can activate pituitary stem cells, but cell numbers are not fully restored, and the ability to mobilize stem cells decreases with increasing age. The basis of these limitations is still unknown.
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- Serum prolactin levels rise from birth to adulthood in rats, with females having higher levels from the start, indicating sex differences not fully explained by hypothalamic factors.
- The study investigated the role of pituitary activins in regulating prolactin secretion, finding maximum expression of relevant activin subunits in young female rats that decreases with age, while male rats show a significant increase in specific subunits as they mature.
- The research concluded that the inhibitory effect of activins on prolactin secretion is sex-specific and more pronounced in females during early life, which contributes to the observed differences in serum prolactin levels as they grow.
Gender differences in a wide variety of physiological parameters have implicated the ovarian hormones, estrogens and progesterone, in the regulation of numerous nonreproductive tissue functions. Rapid, nongenomic (nonclassical) progesterone actions mediated by membrane progesterone receptors (mPRs), which belong to the progestin and adipoQ receptor family, have been extensively investigated in reproductive and nonreproductive tissues since their discovery in fish ovaries 20 years ago. The 5 mPR subtypes (α, β, γ, δ, ε) are widely distributed in vertebrate tissues and are often expressed in the same cells as the nuclear progesterone receptor (PR) and progesterone receptor membrane component 1, thereby complicating investigations of mPR-specific functions.
View Article and Find Full Text PDFSex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons.
View Article and Find Full Text PDFAmong pituitary adenomas, prolactinomas are the most frequently diagnosed (about 50%). Dopamine agonists are generally effective in the treatment of prolactinomas. However, a subset of about 25% of patients does not respond to these agents.
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