Publications by authors named "M A C Gabrielli"
Background/objectives: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons leading to debilitating motor and non-motor symptoms. Beyond its well-known neurological features, emerging evidence underscores the pivotal role of the gut-brain axis and gastrointestinal microbiota in PD pathogenesis. Dysbiosis has been strongly linked to PD and is associated with increased intestinal permeability, chronic inflammation, and the production of neurotoxic metabolites that may exacerbate neuronal damage.
View Article and Find Full Text PDFBackground/objectives: Sepsis is a life-threatening condition characterized by an imbalanced immune response to infection, posing a significant challenge in hospital settings due to its high morbidity and mortality rates. While much attention has been given to patients in the ICU, uncertainties remain regarding the nutritional management of septic patients in non-intensive wards. This narrative review aims to address these gaps by exploring key aspects of nutritional care in sepsis patients admitted to non-intensive wards.
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- Hypovitaminosis D is linked to the development of atherosclerosis and is more common in women, but its specific effects on coronary artery disease (CAD) severity between genders are not well understood.
- A study involving 1,484 patients with acute myocardial infarction found that women had significantly lower vitamin D levels and a higher prevalence of severe CAD when experiencing hypovitaminosis D compared to those without it.
- Furthermore, women with both hypovitaminosis D and diabetes mellitus faced over three times the risk of severe CAD compared to those without either condition.
Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) and type 2 myocardial infarction (MI), both presenting as non-ST-elevation MI (NSTEMI), are often grouped together due to overlapping symptoms. The aim of our study is to compare their characteristics and prognosis to distinguish between them.
Methods: Among 7815 patients with NSTEMI who underwent coronary angiography between 2005 and 2022 we identified 538 patients with diagnosis of MINOCA (n = 301; 3,9 %) and type 2 MI (n = 237; 3 %).
Article Synopsis
- * The study found that MSCs influence microglia, the brain's immune cells, to adopt pro-regenerative functions by altering the extracellular matrix in response to inflammation.
- * Key findings showed that MSC secretome leads to changes in microglial behavior, enhancing their mobility and cellular structures, which are important for promoting healing in the brain.