Publications by authors named "M A Bronstein"
Background: Obesity is a known risk factor for thromboembolic complications in trauma patients. The aim of our study is to evaluate the prevalence of thrombotic complications in obese geriatric patients.
Methods: We performed a retrospective analysis of TQIP (2017-2019).
Article Synopsis
- - Structure-based drug design (SBDD) focuses on creating small molecules that accurately target specific proteins, using structural data to help propose new drug candidates.
- - Current methods typically require extensive dataset preparation and retraining for different tasks, while our approach introduces a single pretrained model that can handle multiple design challenges.
- - We introduce DiffSBDD, a diffusion model that generates new ligands based on protein structures, and demonstrate how it can be enhanced with constraints for better drug candidate quality.
Geriatric falls: an enormous economic burden compared to firearms.
Trauma Surg Acute Care Open
August 2024
Background: This study aimed to assess the medical costs, and the combined costs of fatal firearm injury and fatal falls during a 5 year period. While fatal firearm injury represents a significant public health concern, the healthcare community is faced with the significant challenge of fatal falls, particularly in light of the elderly population growth.
Methods: Data were exported from the Web-based Injury Statistics Query and Reporting System database for fatal firearm and falls in patients aged between 15-85 years-old.
Article Synopsis
- De novo protein design aims to create new proteins that evolution hasn't explored, with challenges in developing structural templates to guide the design process.* -
- Researchers introduced "Genesis," a convolutional variational autoencoder, which effectively learns protein structure patterns and collaborates with trRosetta to design sequences for various protein folds.* -
- The team demonstrated Genesis's ability to replicate native-like structural features in both known and novel protein folds, showcasing its potential for rapid protein design while addressing designability issues effectively.*
Article Synopsis
- Unplanned transfers from the General Ward to Critical Care Units often happen when a patient's condition worsens, leading to longer hospital stays and increased mortality rates.
- A study conducted on 8,317 admissions found that 124 patients (14 per 1,000) were transferred, primarily elderly individuals with conditions like hypertension, heart failure, and respiratory issues.
- The findings indicate that a significant number of patients who were transferred showed stable NEWS scores beforehand, highlighting potential inadequacies in monitoring and care processes in the General Ward.