Publications by authors named "M A Bouche Pillon"
Currently, risk stratification for pediatric Hodgkin lymphoma is based on clinical factors such as stage, bulk, and systemic symptoms. Novel minimally invasive biomarkers could enhance both prognosis and treatment strategies. Therefore, the plasma extracellular vesicles' microRNA profile was characterized by small RNA sequencing in 36 classical Hodgkin lymphoma cases and these findings were confirmed in an extended cohort of 86 patients by RT-qPCR.
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- Burkitt lymphoma (BL) is a common type of B-cell lymphoma in kids, with many being cured but some showing resistance to treatment.
- Researchers used single-cell transcriptomics to study the differences between patients who respond to therapy and those who don’t, finding that non-responders have more immune cells and a specific gene, Tropomyosin 2 (TPM2), highly expressed in their tumors.
- The study suggests that the level of TPM2 can help predict treatment outcomes for BL patients, highlighting the disease's genetic diversity and potential biomarkers for therapy resistance.
Article Synopsis
- MYC is a critical driver of cancer that enhances gene expression and increases RNA production, contributing to tumor growth and survival.
- The study reveals that MYC triggers RNA degradation, leading to toxic byproducts that cause cancer cell death, indicating a new mechanism for targeting MYC-driven cancers.
- Therapeutic strategies that intensify the breakdown of RNA could serve as effective treatments for aggressive cancers like triple-negative breast cancer (TNBC) that rely on MYC.
At present, magnetic confinement fusion devices rely solely on absolute neutron counting as a direct way of measuring fusion power. Absolute counting of deuterium-tritium gamma rays could provide the secondary neutron-independent technique required for the validation of scientific results and as a licensing tool for future power plants. However, this approach necessitates an accurate determination of the gamma-ray-to-neutron branching ratio.
View Article and Find Full Text PDFGlucocorticoids (GCs) are still the mainstay of treatment of giant cell arteritis (GCA). Although GCs are highly effective in GCA, the high burden of toxicity of GCs as well as the disease relapse during GC tapering is well documented. To compare the efficacy and rapidity of TCZ and MTX as steroid-sparing agents in a real-life cohort of GCA patients.
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