Publications by authors named "M A Bonnyns"

[Thyroid and AIDS].

Rev Med Brux

November 1995

Two types of thyroid biochemical abnormalities (TBA) are observed in AIDS. The unspecific TBA are similar to TBA reported in the Euthyroid Sick Syndrome. An increased serum TBG of unknown origin and a decreased circulating rT3 are the most specific TBA of AIDS.

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After mastectomy and radiation for breast cancer, two patients were found to have persistent elevated CEA in their serum. This finding was erroneously attributed to occult metastases for the first patient and to local recurrence for the second. Overlooked medullary thyroid carcinoma (MTC) was the causal disease in both patients.

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To evaluate the influence of age on clinical findings of thyroid disease, the records of 209 consecutive hospitalized patients with hyperthyroidism (n = 109) or hypothyroidism (n = 100) over a ten year period (1979 to 1988) were retrospectively reviewed. Patients included 51 males and 158 females, aged 21-99 years. Control euthyroid subjects (n = 70) were selected in the same age range and for similar non-thyroid illness as patients.

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Over a 2-year period, thyroid function was studied in 102 patients infected with the human immunodeficiency virus (HIV) and in 102 age- and sex-matched controls with various infectious diseases. Biochemical abnormalities were observed in 1-20% of the patients, depending on thyroid indices, but thyroid disease (hypothyroidism) was diagnosed in only 1. Compared to controls, patients, especially those with the acquired immunodeficiency syndrome (AIDS), had a significant increase in serum thyroxine-binding globulin, a lower T3 and free thyroxine index, and a higher frequency of thyroglobulin antibodies.

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