Publications by authors named "M A Bona"
Boraginaceae plants, including four endemic species from Türkiye, were analyzed for organic and inorganic compositions using ICP-MS and LC-MS/MS to explore their nutritional, medicinal, and ecological significance. This study examined 18 species, identifying key elements such as sodium (87,600.359-118,049.
View Article and Find Full Text PDFHigh-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.
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- Pyridoxine-dependent epilepsy (PDE) is a rare genetic disorder linked to abnormal lysine metabolism, with current diagnostics relying on unreliable biomarkers that are unstable and technically challenging to analyze.
- A new method was developed using LC-MS/MS to quantify two alternative biomarkers (2-OPP and 6-oxoPIP) from urine and plasma samples, which showed excellent stability and linearity in testing.
- This validated method offers a promising routine diagnostic tool for identifying and monitoring PDE in patients, potentially improving clinical outcomes.
Ischaemic tolerance induced by remote ischaemic conditioning (RIC) has been extensively demonstrated in several preclinical models of cerebral ischaemia. However, animals with common stroke-related comorbidities do not benefit from the recent advances of RIC. Therefore, we investigated two alternative approaches for obese animals with stroke: (1) the efficacy of an additional round of the standard RIC protocol, and (2) the paracrine potential of the blood cell-derived secretome derived from RIC-induced healthy young rats.
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- Non-pharmacological interventions could improve quality of life for individuals with primary progressive aphasia (PPA) and their caregivers but need more efficacy trials.
- The Communication Bridge-2 (CB2) trial is the first international, video chat-based randomized controlled trial focusing on speech-language interventions for PPA.
- The trial successfully recruited and randomized 95 participant dyads across four countries, demonstrating that global recruitment for non-drug trials in this field is feasible and may serve as a model for future research in Alzheimer's and related dementias.