Publications by authors named "M A Bologna"
Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3 mice showed an enhanced nigro-striatal damage and microglial activation in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
View Article and Find Full Text PDFEssential tremor (ET) is characterized by upper limbs action tremor, sometimes extending to other body parts. However, ET can present with additional neurological features known as "soft signs." These signs of uncertain clinical significance are not sufficient to suggest an alternative neurological diagnosis, and include, among others, questionable dystonia and subtle voluntary movement alterations, i.
View Article and Find Full Text PDFBackground: Risk-stratification of patients with retroperitoneal sarcomas (RPS) relies on validated nomograms, such as Sarculator. This retrospective study investigated whether radiomic features extracted from computed tomography (CT) imaging could i) enhance the performance of Sarculator and ii) identify G3 dedifferentiated liposarcoma (DDLPS) or leiomyosarcoma (LMS), which are currently consider in a randomized clinical trial testing neoadjuvant chemotherapy.
Methods: Patients with primary localized RPS treated with curative-intent surgery (2011-2015) and available pre-operative CT imaging were included.
Article Synopsis
- SARS-CoV-2 infection has negatively affected public health, leading to new or worsened neurological symptoms in some individuals, particularly in those with essential tremor (ET).
- A study examined the effects of SARS-CoV-2 infection on 36 ET patients, finding that 44% of those who contracted the virus reported a subjective worsening of their tremor after infection.
- The analysis showed that while clinical data indicated a decline in tremor for infected patients, kinematic measurements remained stable, suggesting that long COVID might intensify the impact of tremor on daily life for those affected.
Article Synopsis
- * A specific case is presented of a 53-year-old male who experienced progressive myoclonus-ataxia and was found to have a new genetic variant (c.3835G > A) in the CACNA1G gene.
- * The study suggests that this novel variant may affect calcium channel activity and emphasizes the significance of genetic testing for understanding myoclonus-ataxia disorders.