Publications by authors named "M A Boim"
Article Synopsis
- - UC-EVs (umbilical cord mesenchymal stem cell-derived extracellular vesicles) are promising natural nanocarriers that can deliver miRNA-126, which helps maintain blood vessel health and protects kidneys from injury.
- - The study tested the effectiveness of UC-EVs carrying miRNA-126 and anti-miRNA-126 on kidney cells exposed to damage from gentamicin, showing improved cell cycle regulation and reduced DNA damage.
- - Results suggest that UC-EVs not only transport beneficial miRNA but may also contain other protective components that enhance their nephroprotective effects in kidney injury scenarios.
Unlabelled: Containing information molecules from their parent cells and inclining to fuse with targeted cells, bone marrow mesenchymal stromal cells-derived extracellular vesicles (MSCs- EV) are valuable in nanomedicine.
Background: The effects of aging on the paracrine mechanism and in the production and action of MSCs-EV and their cargos of miR-26a and siRNA-26a for the treatment of tubular renal cells under nephrotoxicity injury remain unelucidated.
Objective: The purpose of this study was to evaluate MSCs-EV of different ages and their ability to deliver the cargos of miR-26a and siRNA-26a to target renal tubular cells affected by nephrotoxicity injury.
The fibrogenic process plays a significant pathophysiological role in the progression of chronic kidney disease. Inhibition of the renin-angiotensin system (RAS) is one strategy to delay disease progression but does not reverse established fibrosis. In this context, induced pluripotent stem cells (iPSCs) have been considered an alternative due to their regenerative potential.
View Article and Find Full Text PDFReverse transcription-quantitative polymerase chain reaction (RT-PCR) is the gold standard technique for gene expression analysis, but the choice of quantitative reference genes (housekeeping genes, HKG) remains challenging. Identify the best HKG is essential for estimating the expression level of target genes. Therefore, the aim of this study was to determine the best HKG for an in vitro model with mouse mesangial cells (MMCs) stimulated with 5 ng/mL of TGF-β.
View Article and Find Full Text PDFSepsis contributes to the high prevalence of acute kidney injury (AKI), which mainly occurs in hospitalized patients. The delay in AKI detection is a risk factor for death and chronicity; thus, early diagnosis is essential for initiating proper treatment strategies. Although serum creatinine is used as biomarker, it is increased in plasma serum creatinine only at late stages of AKI.
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