Publications by authors named "M A Binns"
White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and dementia, and are commonly observed in aging, vascular cognitive impairment, and neurodegenerative diseases. The reliable and rapid measurement of WMH in large-scale multisite clinical studies with heterogeneous patient populations remains challenging, where the diversity of imaging characteristics across studies adds additional complexity to this task.
View Article and Find Full Text PDFIntroduction: Elevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized.
Methods: Participants clinically diagnosed with Alzheimer's disease or mild cognitive impairment (AD/MCI), frontotemporal dementia, Parkinson's disease, or cerebrovascular disease were stratified by the presence of the APOE ε4 allele. Volumetric magnetic resonance imaging, plasma amyloid/tau/neurodegeneration biomarkers, and cognitive performance were quantified.
Article Synopsis
- The ASPIRE intervention aims to enhance the daily life performance of older adults with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) over a 10-week period.
- It was compared to a Brain Education control group to evaluate its effectiveness in improving daily activities and overall satisfaction, along with health-related quality of life and cognitive test performance.
- The study utilized a double-blind, randomized controlled trial design involving 264 older adults, with evaluations conducted over six months to assess the sustainability of any improvements.
Article Synopsis
- The Kimel Family Centre is conducting a two-year study to assess personalized dementia risk reduction programs aimed at lowering dementia risk and improving cognitive health in participants aged 50 and older.
- Participants will undergo a thorough dementia risk assessment to receive tailored reports that address their specific health risk factors across five domains: physical activity, nutrition, cognitive engagement, social connections, and mental wellbeing.
- About 450 participants will select programs based on their individual strategies, with assessments happening every six months and annually to track changes in their dementia risk and cognitive health.
Introduction: We investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerative diseases.
Methods: A mediation analysis was performed to assess the relationship between neuroimaging markers and plasma biomarkers on sEF in 333 participants clinically diagnosed with Alzheimer's disease/mild cognitive impairment, frontotemporal dementia, or cerebrovascular disease from the Ontario Neurodegenerative Disease Research Initiative.
Results: PVS was significantly associated with sEF (c = -0.