Publications by authors named "M A Bilotas"
Article Synopsis
- Metabolic syndrome (MS) negatively impacts reproductive health in female mice, leading to issues like disrupted estrous cycles and impaired reproductive success.
- In the study, mice on a high-fat diet showed signs of MS, such as insulin resistance and hormonal imbalances, which affected their endometrial health and reproductive outcomes.
- Treatment with metformin improved these reproductive issues by normalizing hormone levels and restoring proper endometrial function, suggesting potential benefits for women with MS seeking to enhance reproductive health.
Background: Dysregulated hyaluronic acid (HA) metabolism has been shown to be implicated in several pathologies including endometriosis. 4-Methylumbelliferone (4MU) is an HA synthesis inhibitor with proven antitumour activity. In this study, we aim to evaluate the effect of 4MU on endometriosis development both in vivo and in vitro.
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- Endometriosis is a painful condition where tissue similar to the uterine lining grows outside the uterus, and current treatments often fail to alleviate the symptoms.
- Researchers tested the effects of urolithins A (UA) and B (UB) on endometriotic-like lesions in a mouse model, finding that UA completely prevented the lesions while UB reduced their size.
- Both treatments did not impact the mice's body weight or reproductive cycles, suggesting they could offer a promising therapeutic option for managing endometriosis.
Endometriosis is a common and challenging condition of reproductive-aged women that is defined as the presence of endometrial-like tissue outside the uterine cavity. Despite its prevalence, there is still no effective therapeutics; so we aim to evaluate the ellagic acid (EA) effect on the most relevant aspects that are known to be altered in endometriosis. Endometrial primary cultures from women with and without endometriosis and endometrial cell lines were incubated with EA (50 and 100 μM) for 24 and 48 h.
View Article and Find Full Text PDFBased on the inflammatory nature and hormone-dependency of endometriosis, PI3K/AKT signaling appears to influence its progression. Could the endometriosis stages be linked to differential changes in PI3K/AKT pathway regulation? The objective is to evaluate the expression of PI3K, PTEN, AKT and p-AKT in endometrial human biopsies, according to the presence or absence of the disease, and to assess the underlying differences regarding the endometriosis stages. Biopsy specimens of the ectopic and eutopic endometrium were obtained from twenty women with untreated peritoneal endometriosis as well as endometrium biopsies from nine controls.
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