Publications by authors named "M A Benavente"
Background: Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials.
Methods: NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository.
Natural killer (NK) cells destroy tissue that have been opsonized with antibodies. Strategies to generate or identify cells with increased potency are expected to enhance NK cell-based immunotherapies. We previously generated NK cells with increased antibody-dependent cell mediated cytotoxicity (ADCC) following treatment with kifunensine, an inhibitor targeting mannosidases early in the N-glycan processing pathway.
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- The study examines factors affecting health-related quality of life (HRQoL) in patients with chronic kidney disease (CKD), focusing on potentially modifiable aspects that could be targeted for improvement.
- Researchers analyzed data from nearly 3000 CKD patients, collecting diverse information and using specific measures to assess HRQoL, finding that a significant percentage reported issues in various life dimensions.
- Results indicated that poorer HRQoL was strongly associated with obesity, depression, anxiety, medication burden, sarcopenia, low hemoglobin levels, and pain, highlighting areas for potential intervention.
Canine mammary carcinomas (CMC) are associated with major aggressive clinical behavior and high mortality. The current standard of care is based on surgical resection, without an established effective treatment scheme, highlighting the urgent need to develop novel effective therapies. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis and progression in the majority of solid cancers, including human and canine mammary carcinomas.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for clinically important outcomes in persons with CKD referred to secondary care.
Methods: Eligible participants with CKD stages G3-4 or stages G1-2 plus albuminuria >30 mg/mmol were enrolled from 16 nephrology centres in England, Scotland and Wales from 2017 to 2019.