Publications by authors named "M A Ben Saddik"

Article Synopsis
  • Vitiligo affects 0.5 to 2% of the global population and existing treatments are not very effective; this study explored a new film-forming gel using 5 fluorouracil (5FU) to address this issue.
  • The researchers used a specific design to evaluate how different ratios of hydroxypropyl methylcellulose (HPMC) and Zein in the gel impacted drug release, finding that higher HPMC increased 5FU release, while more Zein decreased it.
  • Clinical tests showed that patients treated with the 5FU gel after laser treatment had better outcomes, including reduced JAK3 gene expression, indicating the gel's potential as an effective treatment for vitiligo.
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Background: Patients with obesity presenting in need of surgical intervention are at 2-to-sixfold higher risk of prolonged hospitalization, infectious morbidity, venous thromboembolism, and more. To mitigate some of these concerns, prescribed preoperative weight loss via very low-energy diets (VLEDs) has become a standard of care for patients with obesity undergoing bariatric surgery. While VLEDs have become standard prior to bariatric surgery, their application in other surgical settings remains limited.

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Background: Preoperative very low energy diet (VLED) interventions are used routinely in patients undergoing bariatric surgery, a surgical subspecialty that deals almost exclusively with patients with obesity. Yet, their use and study has been limited in non-bariatric abdominal surgery. To investigate the use of VLEDs in non-bariatric surgery, we plan on conducting a randomized controlled trial (RCT).

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Infected wounds pose a significant challenge in healthcare, requiring innovative therapeutic strategies. Therefore, there is a critical need for innovative pharmaceutical materials to improve wound healing and combat bacterial growth. This study examined the efficacy of azithromycin-loaded silver nanoparticles (AZM-AgNPs) in treating infected wounds.

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Prostate cancer is the second most common cancer in men. Two common radiotherapy techniques, intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT), are used for treatment. This study aimed to compare the two techniques for sparing the bladder and bowel.

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