Publications by authors named "M A Beliakov"

Article Synopsis
  • Both peripheral neuropathy and depression associated with diabetes can result from sodium-calcium imbalance, prompting a study on the drug KB-R7943 as a potential treatment in a rat model.
  • The pharmacokinetic study showed differences in drug exposure and distribution between diabetic rats and controls, with notable accumulation in the brain and heart, but lower penetration in diabetic rats.
  • Chronic treatment with KB-R7943 demonstrated dose-dependent improvement in neuropathic and depression-like symptoms, indicating its potential for treating neurodegenerative effects of diabetes, although further safety studies are needed.
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When 17 patients were surgically treated for spinal tuberculosis and osteomyelitis, anterior spine fusion was performed by A. Ye. Garbuz's procedure that was based on the replacement of a spinal defect by a carbon-carbonic implant that had rifampicin containers in the frontal sections, as well as by autologous bone grafts.

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For surgical treatment of spinal tuberculosis, carbon-carbonic implants were used for anterior spondylosis in 29 patients; in 14 of them bone autografts were additionally applied. Carbon-carbonic implants reliably fixed the operated part of the vertebral column, prevented an increase in kyphotic deformity, and, in combined plastic repair, created favorable conditions for consolidation of bone autografts. A bone-carbon block formed in the late postoperative period.

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Based on the experience gained in surgery for varicose veins of the lower limbs, the authors discuss the strategy of conduction anesthesia and the necessity of replacing it with the alternative analgetic methods. Conduction anesthesia implies that variants of anesthesiologic provision are specified, based on the results of conduction anesthesia and the patient's status; if a physician doubts whether the nerve block or patient's behavior controllability are full-value, he should resort to combined anesthesia; the surgeon's manipulations in nerve blocking should not increase the risk or limit the use of alternative methods of analgesia.

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