Publications by authors named "M A Bedaiwy"
Study Question: Is there an association between the somatic loss of PTEN (phosphatase and tensin homolog) and ARID1A (AT-rich interaction domain 1A) and endometriosis disease severity and worse clinical outcomes?
Summary Answer: Somatic PTEN loss in endometriosis epithelium was associated with greater disease burden and subsequent surgical complexity.
What Is Known Already: Somatic cancer-driver mutations including those involving the PTEN and ARID1A genes exist in endometriosis without cancer; however, their clinical impact remains unclear.
Study Design, Size, Duration: This prospective longitudinal study involved endometriosis tissue and clinical data from 126 participants who underwent surgery at a tertiary center for endometriosis (2013-2017), with a follow-up period of 5-9 years.
Article Synopsis
- The study aimed to evaluate how perimenopausal and postmenopausal women in British Columbia perceive reproductive aging and their concerns about endometrial cancer (EC).
- Interviews with 31 women revealed a simplistic understanding of midlife changes, a tendency to "tough it out," and low awareness of EC risk factors, with confusion between cervical cancer and EC.
- Participants expressed the need for better education on EC and recommendations for raising awareness about it during discussions on perimenopause and menopause.
The utility of pre-implantation genetic testing (PGT-A) is controversial, with older meta-analyses demonstrating improved pregnancy outcomes, while newer trials have not shown benefit. Therefore, we performed a meta-analysis which aimed to evaluate the benefits of PGT-A using comprehensive chromosome screening (CCS) and its effects on fertilization (IVF) outcomes among randomized controlled trials (RCTs). We conducted a systematic search to identify RCTs comparing women undergoing PGT-A with CSS with women not undergoing PGT-A, from inception to December 2020.
View Article and Find Full Text PDFArticle Synopsis
- Chronic Intervillositis of Unknown Etiology (CIUE) is a rare inflammatory disorder of the placenta linked to poor pregnancy outcomes and a high risk of recurrence, reaching as much as 100%.
- A thorough meta-analysis reviewing 19 relevant studies found that CIUE is associated with decreased live birth rates (53%), increased pregnancy loss (23%), and various complications such as gestational hypertension and preterm births.
- Although no significant improvement in live birth rates was noted for treated patients, the findings highlight the need for more research on this rare condition due to its complex nature and potential risks.