Publications by authors named "M A Bebars"
Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.
Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.
Objective: This is a comprehensive characteristic study of Kawasaki disease (KD) and Multi system inflammatory syndrome in children (MIS-C) in the Middle East that creates a formula to differentiate between the two.
Methods: We conducted a descriptive comparative study of KD and MIS-C in the United Arab Emirates. Retrospective MIS-C and KD cohorts were recruited between January 2017 until August 2021.
Background: Multiloculated hydrocephalus (MLH) is associated with increased intracranial pressure, with intraventricular septations, loculations, and isolation of parts of the ventricular system. Search continues for ideal surgical remedy capable of addressing the dimensions of the problem. We aimed to evaluate endoscopic septal fenestration and pellucidotomy combined with proximal shunt tube refashioning and further advancement into isolated loculations of the ventricular system containing choroid plexus.
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- Previous research shows that tumor processes like angiogenesis and metastasis are influenced by the blood coagulation system, particularly tissue factor (TF), which also affects cell signaling related to cancer progression.
- In a study involving 40 neuroblastoma tissue samples, 75% showed positive TF expression, with a significant correlation between TF levels and the MYCN gene's upregulation, indicating a potential link between these factors.
- TF expression was found to be a significant predictor of patient outcomes, with 60% of patients with positive TF expression dying from the disease, suggesting that TF might be a valuable prognostic marker and a target for future treatments in neuroblastoma.