Publications by authors named "M A Beaudin"
Background: Support for the treatment of uncomplicated appendicitis with non-operative management rather than surgery has been increasing in the literature. We aimed to investigate whether treatment of uncomplicated appendicitis with antibiotics in children is inferior to appendicectomy by comparing failure rates for the two treatments.
Methods: In this pragmatic, multicentre, parallel-group, unmasked, randomised, non-inferiority trial, children aged 5-16 years with suspected non-perforated appendicitis (based on clinical diagnosis with or without radiological diagnosis) were recruited from 11 children's hospitals in Canada, the USA, Finland, Sweden, and Singapore.
Article Synopsis
- The study highlights the significance of reducing low-value care in pediatric trauma, suggesting that it can enhance patient experiences and outcomes while minimizing unnecessary healthcare resource use.* -
- A retrospective cohort study involving over 10,700 children admitted to trauma centers in a Canadian province was conducted to identify and assess low-value practices in pediatric trauma care.* -
- The research found 19 low-value practices, with five showing moderate to high frequency and variation across hospitals, indicating a need for standardized care to improve pediatric trauma treatment.*
Article Synopsis
- A multicenter study involving 13 pediatric trauma centers examined the effects of a standardized non-operative management (NOM) approach for children with blunt traumatic pancreatic laceration and ductal injury between 2018-2022.
- Results showed that most patients recovered quickly with a low-fat diet starting after a median of 4 days, and hospital stays averaging 8 days, while complications like cyst development were significantly reduced compared to a historical variable management cohort.
- The findings suggest that using a consistent NOM protocol can improve patient outcomes and that pancreatic ascites at presentation might indicate a higher risk of developing pseudocysts in these cases.
The importance of synthetic pharmacotherapy for recessive cerebellar ataxias.
Expert Rev Neurother
September 2024
Introduction: The last decade has witnessed major breakthroughs in identifying novel genetic causes of hereditary ataxias, deepening our understanding of disease mechanisms, and developing therapies for these debilitating disorders.
Areas Covered: This article reviews the currently approved and most promising candidate pharmacotherapies in relation to the known disease mechanisms of the most prevalent autosomal recessive ataxias. Omaveloxolone is an Nrf2 activator that increases antioxidant defense and was recently approved for treatment of Friedreich ataxia.
Article Synopsis
- - The study explored whether healthy children show attentional bias towards threats similar to clinically anxious kids, potentially helping identify those at risk for anxiety issues earlier in life.
- - Researchers assessed the role of parent-child attachment security in the relationship between anxiety vulnerability factors (like anxiety sensitivity and uncertainty) and attentional bias towards angry stimuli.
- - Findings indicated that children with higher anxiety vulnerability detected anger-related stimuli faster, and this effect was moderated by stronger maternal attachment security, hinting at cognitive patterns found in anxious children and suggesting avenues for early detection of anxiety disorders.