Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.

Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been implicated in glioma-induced neuronal hyperexcitability, but the molecular and functional consequences have not been identified. Here, we show three types of changes in tumor-associated neurons: (1) downregulation of transcripts encoding excitatory and inhibitory postsynaptic proteins and dendritic spine development and upregulation of cytoskeletal transcripts via neuron-specific profiling of ribosome-bound mRNA, (2) marked decreases in dendritic spine density via light and electron microscopy, and (3) progressive functional alterations leading to neuronal hyperexcitability via in vivo calcium imaging.

Enhancing Access to Mental Health Services for Antepartum and Postpartum Women Through Telemental Health Services at Wellbeing Centers in Selected Health Facilities in Bangladesh: Implementation Research.

Background: Globally, 10% of pregnant women and 13% of postpartum women experience mental disorders. In Bangladesh, nearly 50% of mothers face common mental disorders, but mental health services and trained professionals to serve their needs are scarce. To address this, the government of Bangladesh's Non-Communicable Disease Control program initiated "Wellbeing Centers," telemental health services in selected public hospitals.

Anti-Bacterial and Anti-Dermatophytic Activity of Extracellular Secondary Metabolites of Streptomyces glaucescens NTSB-37 Isolated from Lichen Parmotrema perlatum (Huds.) M. Choisy in Kolli Hills, Tamil Nadu, India.

Lichen-associated endophytic Actinobacteria, particularly Streptomyces species, are recognized for their production of bioactive secondary metabolites with significant pharmaceutical potential. With the escalating prevalence of diseases, Streptomyces species are being investigated for its natural source of antimicrobial compounds for new antibiotics. This study focuses on the bioactive properties of secondary metabolites from lichen-associated endophytic Actinobacteria, focusing on Streptomyces glaucescens NTSB-37 isolated form lichen, Parmotrema perlatum (Huds.

An assessment of the influence of dentinal pretreatment with chlorhexidine, nonthermal atmospheric plasma, chitosan, and proanthocyanidins on shear bond strength to composite.

Context: Dentin biomodification has been emphasized as a means of improving the bond between composite resin and tooth surface, consequently enhancing its longevity.

Aim: To evaluate the shear bond strength (SBS) of dentin after pretreatment with 2% chlorhexidine (CHX), 2% chitosan, nonthermal atmospheric plasma (NTAP), proanthocyanidins (5% pine bark ((PB) and 5% bromelain).

Settings And Design: The study was designed as an investigation.

Effect of nonthermal atmospheric plasma application at different time intervals on the dentinal shear bond strength pretreated with 2% chlorhexidine as cavity disinfectant: An study.

Context: Effective use of nonthermal atmospheric plasma (NTAP) to strengthen adhesive-dentin interfacial bonding while disinfecting with chlorhexidine (CHX).

Aim: NTAP application at different time intervals on the dentinal shear bond strength (SBS) after pretreatment with 2% CHX as a cavity disinfectant.

Settings And Design: The design of the study was an study.