Level of Awareness, Screening Practices, and Self-Detection Among Breast Cancer Patients.

Objective: Having good knowledge and performing regular pre-tests under physician supervision play a crucial role in the early detection of breast cancer. The aim of this study was to investigate the level of awareness, frequency of performing routine screening, types of screening methods prior to detection, and who detected the case, among women diagnosed with breast cancer.

Materials And Methods: A cross-sectional study that used a designed questionnaire applied to investigate demographic data and four other aspects: level of awareness, screening practices, type of screening methods used, and who detected the case for the first time.

High early strength concrete incorporating waste derived nanomaterials for sustainable construction.

This paper contributes to the expanding knowledge base on nanomaterial-enhanced cementitious composites, offering valuable insights for developing high-performance, sustainable concrete solutions. The study assessed the effects of three different types of nanomaterials-nano clay (NC), nano silica (NS), and nano cellulose (NCel)-on the compressive strength of high-early-strength concrete (HESC) through both experimental studies and a 2 factorial design. Incorporating nanomaterials into the HESC matrix led to a decrease in workability, with NCel demonstrating the least impact on this property across all studied replacement percentages.

Asparagine availability controls germinal center B cell homeostasis.

The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these metabolic processes are poorly understood. By integrating metabolomic and transcriptomic profiling of GC B cells, we identified that asparagine (Asn) metabolism was highly up-regulated and essential for B cell function. Asparagine synthetase (ASNS) was up-regulated after B cell activation through the integrated stress response sensor GCN2.

Exploring the Potential of Electronic Patient-Generated Health Data for Evaluating Treatment Response to Intramuscular Steroids in Rheumatoid Arthritis: Case Series.

Background: Mobile health devices are increasingly available, presenting exciting opportunities to remotely collect high-frequency, electronic patient-generated health data (ePGHD). This novel data type may provide detailed insights into disease activity outside usual clinical settings. Assessing treatment responses, which can be hampered by the infrequency of appointments and recall bias, is a promising, novel application of ePGHD.