Personality differences between birth order categories and across sibship sizes.

We examined associations of self-reports on the HEXACO Personality Inventory-Revised (HEXACO-PI-R) with birth order category and sibship size, controlling for participant sex and age. In a first sample ( > 700,000 online adults, mainly from English-speaking countries), Honesty-Humility and Agreeableness both showed the highest means for middle-borns, followed in order by last-borns (youngests), firstborns (oldests), and only children, with differences between middles and onlys of ≥ 0.20.

Exploring factors that impact pass rates in a UK pharmacist registration exam, 2011-2024.

Objectives: The aim of this work was to evaluate the performance of UK MPharm graduates on the General Pharmaceutical Council's (GPhC) registration assessment, between the years 2011-2024, to explore the factors that impact student performance in this examination.

Methods: Student performance in the GPhC registration assessment was contextualized with factors like alma mater, Foundation Training placement, NSS, and HESA data. Relationships between these factors and the weighted average passing rates and raw scores were analysed using a range of statistical methods including correlation analysis, ANOM, Tukey-Kramer, and t-tests.

Inequalities in uptake of childhood vaccination in England, 2019-23: longitudinal study.

Objective: To quantify changes in inequalities in uptake of childhood vaccination during a period of steadily declining overall childhood vaccination rates in England.

Design: Longitudinal study.

Setting: General practice data for five vaccines administered to children (first and second doses of the measles, mumps, and rubella vaccine (MMR1 and MMR2, respectively), rotavirus vaccine, pneumococcal conjugate vaccine (PCV) booster, and six-in-one (DTaP/IPV/Hib/HepB) vaccine covering diphtheria, tetanus, pertussis, polio, type b, and hepatitis B) from the Cover of Vaccination Uptake Evaluated Rapidly dataset in England.

Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint.

Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cell cycle arrest prior to anaphase for about 12-15 hr, after which cells 'adapt' to the damage by extinguishing the DDC and resuming the cell cycle. While activation of the DNA damage-dependent cell cycle arrest is well understood, how it is maintained remains unclear.

How Do Mental Disorders and Combinations of Disorders Affect the Odds of Injuries and Poisoning?

Injuries and poisoning are associated with mental disorders. The association may be stronger if comorbid mental illness is involved. This study explores whether selected mental disorders (stress, anxiety, depression, attention deficit hyperactivity disorder [ADHD], bipolar, obsessive-compulsive disorder [OCD], schizophrenia) are associated with injuries and poisoning and if the presence and frequency of comorbid mental illness affect these associations.