Soluble platelet selectin and platelets in COVID-19: a multifaceted connection.

The COVID-19 pandemic has brought to light the intricate relationship between platelets, soluble platelet selectin (sP-selectin), and disease pathogenesis. Platelets, traditionally recognized for their role in hemostasis, have emerged as key contributors to the immunothrombotic complications observed in COVID-19 patients. Concurrently, elevated levels of sP-selectin, indicative of platelet activation and endothelial injury, have been consistently identified in COVID-19 patients and have shown associations with disease severity and adverse outcomes.

Identification of EGFR inhibitors as potential agents for cancer therapy: pharmacophore-based modeling, molecular docking, and molecular dynamics investigations.

Context: As a member of a large family of proteins that together regulate various aspects of cell growth and development, the epidermal growth factor receptor (EGFR) is a validated target for the development of new drugs. Herein, we compiled a library of 62 compounds from the PubChem database with similar pharmacophores as osimertinib, which to our knowledge represents the only drug capable of overcoming EGFR-T790M-mutated NSCLC until date. Subsequently, we launched a docking-based virtual screening campaign against the EGFR kinase with the compiled chemical entities.

Integrated virtual screening and molecular dynamics simulation revealed promising drug candidates of p53-MDM2 interaction.

In the vast majority of malignancies, the p53 tumor suppressor pathway is compromised. In some cancer cells, high levels of MDM2 polyubiquitinate p53 and mark it for destruction, thereby leading to a corresponding downregulation of the protein. MDM2 interacts with p53 via its hydrophobic pocket, and chemical entities that block the dimerization of the protein-protein complex can restore p53 activity.

Anti-hyperlipidemic and antioxidant potentials of aqueous leaf extract of Telfairia occidentalis (fluted pumpkin) in male Sprague-Dawley rats.

In Africa traditional medicine, certain plant leaves are employed in the treatment of metabolic disorders such as dyslipidaemia. Telfairia occidentalis is named among Nigerian plants that are under investigation for anti-hyperlipidemic activity. The antihperlipidemic and antioxidant potentials of Telfairia Occidentalis (TO) aqueous leaf extract were studied in male Sprague- Dawley rats.

Medical waste management at the primary healthcare centres in a north western Nigerian State: Findings from a low-resource setting.

Objectives: This study aims to examine medical waste management (MWM) practices and identify the challenges of optimal MWM at the primary healthcare (PHC) level in Kebbi State, Nigeria.

Study Design: This study was a cross-sectional survey of 265 primary healthcare workers (PHCWs) and health facilities (HFs) in Kebbi State.

Methods: The study tool used was a questionnaire adapted from the WHO rapid assessment tool on MWM and water sanitation.